Table 2.

Demographics and treatment details per patient

Overview of demographical data, tumor characteristics, treatment details and outcomes per patient. The treatment trajectory till the first surgery at the RC was depicted. Patients may have undergone additional treatment after the first surgery at the RC. Compression of the optic chiasm was present in none of the patients at time of surgery. No permanent complications occurred. Biochemical remission was defined as normalization of prolactin. Clinical remission was defined as restoration of gonadal axis and resolution of symptoms, i.e. no indication for further treatment. B bromocriptine, C cabergoline, CSI cavernous sinus invasion, F female, GH growth hormone, M male, Macro macroadenoma, Micro microadenoma, NV not visible, PA histopathology, PRL prolactin, Q quinagolide, RC referral center, subj. subject, TR total resection, TSS transsphenoidal surgery, U unknown, ↑ optimal surgical chance of total resection, ↓ suboptimal surgical chance of total resection, Treatment undergone before referral to the RC, Treatment undergone at the RC

^a6 months after the first surgery performed at the referral center

^bChance of achieving total resection for the patients in whom total resection was the primary surgical goal

^cHemorrhage and tissue that could be preexisting pituitary or adenoma with positive staining for ACTH, growth hormone and to a lesser extent prolactin

^dNo certain adenoma, small area with increased expression of prolactin and growth hormone

^eRemission not expected as the goal of surgery was debulking

^fPatient is a BAP1 gene mutation carrier

^gMedication started in Poland, unknown which agent bold Treatment undergone at the RC

^hDubious expression of growth hormone italic Treatment undergone before referral to the RC

ⁱRemission status was measured 11 months postoperative

^jRemission status measured 2 months postoperative, as the patient was lost to follow-up from this point on

^kUncertain adenoma, possible apoplexy