Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Sep 28;14:6066. doi: 10.1038/s41467-023-41559-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a For each IDH-mutant tumor (listed on horizontal axis), genetic variants have been annotated as private (exclusively occurring in one sample), shared (occurring in two or more samples, but not in all samples) and truncal (occurring in all samples) and reported as a percentage of the total number of somatic variations. The proportion of mutation types was significantly different between CE and NE (two-sided Fisher’s exact test p = 3.43e−67). A schematic example of multiregional tumor evolution is represented as a tree in which truncal, shared, and private branches are distinguished. b Overview of somatic alterations in IDH-mutant samples grouped by patient. Mutation load and tumor purity are reported in the top barplot and heatmap track, respectively. Clinical annotation and gene expression classification are indicated in the bottom tracks. Gene alteration frequency in the patient cohort is indicated as percentage on the left, known with driver mutations highlighted in red. c MEM model derived estimated marginal mean of T2W in IDH-mutant vs. IDH wild-type samples in the NE. Error bars show 95% confidence interval. Two-sided t-test with Tukey correction (n = 86). d MEM model derived estimated marginal mean of EPI + C in IDH-mutant vs. IDH wild-type samples in the NE. Error bars show 95% confidence interval. Two-sided t-test with Tukey correction (n = 89). c, d Data are presented as mean values +/−SD. a, c, d Source data are provided as a Source data file.