Figure 1.

Schematic outline of the study design and a description of the RNA expression datasets used for (A) coexpression network analysis, (B) sTIL correlation, (C) opioid regulation, (D) cell-type specificity, and (E, F) ICI-drug interactions. CIBERSORT, Cell-type Identification by Estimating Relative Subsets of Ribonucleic Acid Transcripts; FUSCC, Fudan University Shanghai Cancer Center; LINCS, Library of Integrated Network-Based Cell Signatures; ORN, opioid-regulated stromal tumor-infiltrating lymphocytes network; PBMC, Peripheral blood mononuclear cells (lymphocytes (T-cells, B-cells, NK cells), monocytes, dendritic cells); TCGA, The Cancer Genome Atlas; TNBC, triple-negative breast cancer. Datasets are labeled as in Table 1 .