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. 2023 Sep 12;77:101797. doi: 10.1016/j.molmet.2023.101797

Figure 1.

Figure 1

Isoxanthohumol (IX) suppresses body weight gain and improves glucose metabolism in mice on a high-fat diet (HFD). (A) Body weight and (B) daily food intake of mice treated with either an HFD (blue) or an HFD + IX (red) (n = 9–10 per group). (C) Oral glucose tolerance test (OGTT), (D) plasma insulin levels at 17 weeks old and (E) insulin tolerance test (ITT) at 16 weeks old. (F) Tissue weight at 20 weeks old (n = 9–10 per group). (G, J) Representative hematoxylin and eosin (H&E)-stained pictures of (G) liver and (J) epididymal adipose tissue at 20 weeks old. Scale bars, 200 μm. (H) Hepatic and (I) plasma triglyceride concentrations at 20 weeks old (n = 15–17 per group). (K) Quantitative PCR analysis of inflammatory and metabolic markers in the epididymal adipose tissues at 20 weeks old (n = 6–7 per group). ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001, by two-way analysis of variance (ANOVA) followed by Bonferroni's multiple comparison tests (A, C, D, E) or unpaired two-tailed t test (B, F, H, I). ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, followed by the Benjamini-Hochberg post-test (q < 0.05) (K). Data are presented as the mean ± SEM.