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. 2023 Sep 12;77:101797. doi: 10.1016/j.molmet.2023.101797

Figure 5.

Figure 5

Compound IX enhances gut barrier function. (A) Representative alcian blue images of the colon. Scale bars, 200 μm. (B) Fecal mucin levels per gram feces of mice fed either an HFD or an HFD + IX (n = 9–10 per group). (C) Western blots for claudin1 and β-actin in the colon of mice at 20 weeks old. (D) Quantitation of claudin1 normalized by β-actin. (E) qPCR of the lipopolysaccharide binding protein in the liver (n = 19 per group). (F) Schematic overview of the transplantation of specific pathogen-free mice with A. muciniphila. (G) Body weights of transplanted mice (n = 5 per group). (H) OGTT. (I) Tissue weight. (J) qPCR of various nutrient transporter-related genes in the jejunum of the transplanted mice (n = 5 per group). ∗P < 0.05, ∗∗P < 0.01, using two-way ANOVA, followed by Bonferroni's multiple comparison tests for (G, H)Wilcoxon rank sum test (E) or by unpaired two-tailed t-test for (B, D, I, J). Data are presented as the mean ± SEM.