Table 1.
The definition, precipitating factors, pathophysiology, clinical characteristics, treatment and prognosis comparison between normal wound healing and diabetic wound healing.
| Normal wound healing | Diabetic wound healing | |
|---|---|---|
| Definition | A dynamic repair process that occurs after a breach of anatomical integrity | Wound healing occurring on the basis of diabetes |
| Precipitating factors | Various external physical and chemical injuries | External injurious factors and the presence of internal hyperglycemia |
| Pathophysiology | ||
| Hemostasis processess | Platelet aggregation Release of vasoactive substances | Platelet hyperaggregation Accelerated local vascular lesions |
| Inflammation processess | Moving and concentrating immune cells toward the wound Release of protease and various cytokines | Unbalanced ratio of M1 and M2 macrophages Uncontrolled inflammatory response |
| Proliferation processess | Epithelialisation Granulation | Decreased angiogenesis Decreased collagen deposition |
| Remodeling processess | Collagen reorganization Scar tissue remodeling |
Interrupted processes of granular tissue to scar tissue Decreased tensile strength |
| Clinical characteristics | Timely wound closure Generally healing without any issue | Delayed wound closure Susceptibility to infection |
| Treatment | Fundamental treatment Vacuum sealing drainage Wound dressings Autologous skin graft Synthetic replacement for tissues | Symptomatic treatment Hyperbaric oxygen therapy Silver nanoparticles Glucose control Infection prevention |
| Prognosis | Favorable prognosis Structural and functional recovery | Unfavourable prognosis Life-threatening in some cases |