Figure 2.

SRSF1 is required for spermatogenesis. (A) The testes of Srsf1^cKO were smaller than those of the control (8-week-old, the same as below). (B) Testis weight of Srsf1^WT and Srsf1^cKO 8-week-old male mice (n=3). (C) Testis weight to body weight ratio of Srsf1^WT and Srsf1^cKO 8-week-old male mice (n=3). Data are presented as the mean ± SEM. P<0.05(*), 0.01(**) or 0.001(***). (D) Histological analysis of the caudal epididymes of the Srsf1^WT and Srsf1^cKO mice. Scale bar: (top) 100 μm; (bottom) 50 μm. (E) Histological analysis of the seminiferous tubules of the Srsf1^WT and Srsf1^cKO mice. Scale bar: (top) 100 μm; (bottom) 50 μm. For this part, at least 3 mice (8-week-old) of each genotype were used for the analysis.