Table 1.

${}^{\mathrm{1}}$ H chemical shifts of idoxifene, free in solution and bound to CaM.

Resonance	Free ${}^{\mathrm{a}}$	Bound ${}^{\mathrm{b}}$
${}^{\mathrm{1}}$ H	$\mathit{\delta }$	$\mathit{\delta }$	$\mathrm{\Delta }\mathit{\delta }$
$\mathrm{16}/\mathrm{18}$	7.52	7.42	$-\mathrm{0.10}$
$\mathrm{15}/\mathrm{19}$	6.86	6.84	$-\mathrm{0.02}$
$\mathrm{21}/\mathrm{25}$	6.69	6.71	$+\mathrm{0.02}$
$\mathrm{22}/\mathrm{24}$	6.47	6.55	$+\mathrm{0.08}$
$\mathrm{7}/\mathrm{11}$	6.99	6.98	$-\mathrm{0.01}$
8, 9, 10 ${}^{\mathrm{c}}$	7.06	7.08	$+\mathrm{0.02}$
12	2.23	2.31	$+\mathrm{0.08}$
13	0.73	0.78	$+\mathrm{0.05}$
26	3.96	4.10	$+\mathrm{0.14}$
27	3.43	3.50	$+\mathrm{0.07}$
$\mathrm{28}/\mathrm{31}$	$\mathrm{3.39}/\mathrm{3.06}$	3.30	$+\mathrm{0.07}$
29/30	1.96	1.99	$+\mathrm{0.03}$

${}^{\mathrm{a}}$ D ${}_{\mathrm{2}}$ O, pH 3.0. ${}^{\mathrm{b}}$ D ${}_{\mathrm{2}}$ O, pH 6.0. ${}^{\mathrm{c}}$ Unresolved resonances.