Table 1.

Experimental parameters used.

		Dimension of acquired data			Spectral width (ppm)			NS ${}^{\mathrm{a}}$	$d_{\mathrm{1}}$ (s) ${}^{\mathrm{b}}$
		t1	t2	t3	F1	F2	F3
Experiments with $\mathit{\alpha }$ -synuclein
${}^{\mathrm{1}}\mathrm{H}$ detected	${}^{\mathrm{1}}\mathrm{H}{-}^{\mathrm{15}}\mathrm{N}$ HSQC	800 ( ${}^{\mathrm{15}}\mathrm{N}$ )	2048 ( ${}^{\mathrm{1}}\mathrm{H}$ )		28.1	15.0		2	1.0
${}^{\mathrm{13}}\mathrm{C}$ detected	CON	512 ( ${}^{\mathrm{15}}\mathrm{N}$ )	1024 ( ${}^{\mathrm{13}}\mathrm{C}$ )		32.0	31.0		2	1.6
	CON ${}^{\mathrm{Pro}}$	128 ( ${}^{\mathrm{15}}\mathrm{N}$ )	1024 ( ${}^{\mathrm{13}}\mathrm{C}$ )		5.0	31.0		2	1.6
	$\left(\mathrm{H}\right){\mathrm{CBCACON}}^{\mathrm{Pro}}$	128 ( ${}^{\mathrm{13}}\mathrm{C}$ )	32 ( ${}^{\mathrm{15}}\mathrm{N}$ )	1024 ( ${}^{\mathrm{13}}\mathrm{C}$ )	60.0	5.0	30.0	4	1.0
	$\left(\mathrm{H}\right){\mathrm{CCCON}}^{\mathrm{Pro}}$	128 ( ${}^{\mathrm{13}}\mathrm{C}$ )	32 ( ${}^{\mathrm{15}}\mathrm{N}$ )	1024 ( ${}^{\mathrm{13}}\mathrm{C}$ )	70.0	5.0	30.0	4	1.0
	$\left(\mathrm{H}\right){\mathrm{CBCANCO}}^{\mathrm{Pro}}$	128 ( ${}^{\mathrm{13}}\mathrm{C}$ )	16 ( ${}^{\mathrm{15}}\mathrm{N}$ )	1024 ( ${}^{\mathrm{13}}\mathrm{C}$ )	60.0	5.0	30.0	8	1.0
${}^{\mathrm{1}}\mathrm{H}$ and ${}^{\mathrm{13}}\mathrm{C}$ detected	CON/HN	600 ( ${}^{\mathrm{15}}\mathrm{N}$ )	1024 ( ${}^{\mathrm{13}}\mathrm{C}$ )		35.0	31.0		2	1.6
(using multiple receivers)		600 ( ${}^{\mathrm{15}}\mathrm{N}$ )	2048 ( ${}^{\mathrm{1}}\mathrm{H}$ )		35.0	15.0		4
Experiments with CBP-ID4
${}^{\mathrm{1}}\mathrm{H}$ detected	${}^{\mathrm{1}}\mathrm{H}{-}^{\mathrm{15}}\mathrm{N}$ HSQC	800 ( ${}^{\mathrm{15}}\mathrm{N}$ )	2048 ( ${}^{\mathrm{1}}\mathrm{H}$ )		30.0	15.0		2	1.0
${}^{\mathrm{13}}\mathrm{C}$ detected	CON	1024 ( ${}^{\mathrm{15}}\mathrm{N}$ )	1024 ( ${}^{\mathrm{13}}\mathrm{C}$ )		38.0	30.0		2	2.0
	CON ${}^{\mathrm{Pro}}$	170 ( ${}^{\mathrm{15}}\mathrm{N}$ )	1024 ( ${}^{\mathrm{13}}\mathrm{C}$ )		6.5	30.0		2	2.0
	$\left(\mathrm{H}\right){\mathrm{CBCACON}}^{\mathrm{Pro}}$	128 ( ${}^{\mathrm{13}}\mathrm{C}$ )	64 ( ${}^{\mathrm{15}}\mathrm{N}$ )	1024 ( ${}^{\mathrm{13}}\mathrm{C}$ )	64.5	6.5	30.0	4	1.0
	$\left(\mathrm{H}\right){\mathrm{CCCON}}^{\mathrm{Pro}}$	128 ( ${}^{\mathrm{13}}\mathrm{C}$ )	64 ( ${}^{\mathrm{15}}\mathrm{N}$ )	1024 ( ${}^{\mathrm{13}}\mathrm{C}$ )	75.7	6.5	30.0	4	1.0
	$\left(\mathrm{H}\right){\mathrm{CBCANCO}}^{\mathrm{Pro}}$	128 ( ${}^{\mathrm{13}}\mathrm{C}$ )	22 ( ${}^{\mathrm{15}}\mathrm{N}$ )	1024 ( ${}^{\mathrm{13}}\mathrm{C}$ )	64.5	6.5	30.0	16	1.0
	$\left(\mathrm{HCA}\right){\mathrm{COCON}}^{\mathrm{Pro}}$	96 ( ${}^{\mathrm{13}}\mathrm{C}$ )	64 ( ${}^{\mathrm{15}}\mathrm{N}$ )	1024 ( ${}^{\mathrm{13}}\mathrm{C}$ )	10.8	6.5	30.0	8	1.5

${}^{\mathrm{a}}$  Number of acquired scans. ${}^{\mathrm{b}}$  Inter-scan delay.