Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Sep 8;28(5):200. doi: 10.3892/mmr.2023.13087

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 2. — Dapagliflozin inhibits PA-induced pyroptosis in MPC5 cells. (A) The protein expression of caspase-1, IL-18 and IL-1β decreased following dapagliflozin treatment. (B) The relative mRNA level of ASC, IL-18 and IL-1β decreased following dapagliflozin treatment in MPC5 cells. (C) Relative cell count ratio of PI uptake. (D) Photomicrographs of double-fluorescent staining with Hoechst 33342/PI. PA, 0.2 mmol; Dapa, 2 µmol; scale bar, 100 µm. *P<0.05, **P<0.01 vs. control group; ^#P<0.05 vs. PA group. Con, control; Dapa, dapagliflozin; MPC5, mouse podocyte clone 5; PA, palmitic acid; ASC, apoptosis-associated speck-like protein containing a caspase activation and recruitment domain; PI, propidium iodide.