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. 2023 Sep 8;28(5):200. doi: 10.3892/mmr.2023.13087

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — HO-1 overexpression inhibits PA-induced pyroptosis in MPC5 cells. (A) HO-1 overexpression decreased the expression of NLRP3, caspase-1, IL-18 and IL-1β in MPC5 cells. (B) HO-1 overexpression decreased the relative mRNA level of NLRP3, caspase-1, IL-18 and IL-1β in MPC5 cells. (C) Relative cell count ratio of PI uptake. (D) Photomicrographs of double-fluorescent staining with Hoechst 33342/PI. PA, 0.2 mmol; scale bar, 100 µm. *P<0.05, **P<0.001, ***P<0.001 vs. control group; ^#P<0.05, ^##P<0.01, ^###P<0.001 vs. PA group. HO-1, heme oxygenase 1; MPC5, mouse podocyte clone 5; NLRP3, NOD-like receptor thermal protein domain associated protein 3; PA, palmitic acid; Con, control; Dapa, dapagliflozin.