TABLE 1.
MICs of amphotericin B and itraconazole for nine mold isolates used to treat infections in animalsa
| Fungal isolate | Amphotericin B MIC (μg/ml)
|
Itraconazole MIC (μg/ml)
|
||
|---|---|---|---|---|
| Mode | Range | Mode | Range | |
| A. flavus 01 | 1 | 0.5–4 | 0.5 | 0.12–0.5 |
| A. fumigatus 10 | 1 | 0.5–2 | 0.25 | 0.12–1 |
| F. oxysporum 15 | 2 | 1–4 | >16 | 4–>16 |
| F. oxysporum 15a | 2 | 1–4 | >16 | 8–>16 |
| F. solani 16 | 1 | 0.5–2 | >16 | >16 |
| P. boydii 24 | 4 | 2–8 | 1 | 0.25–1 |
| P. boydii 25 | 4 | 4–16 | 1 | 0.5–4 |
| R. arrhizus 26 | 0.25 | 0.12–0.5 | 2 | 0.5–4 |
| R. arrhizus 27 | 0.25 | 0.25–0.5 | >16 | 2–>16 |
a
The modal MICs and ranges were recorded in 11 laboratories after 24 h of incubation (R. arrhizus) or 48 h of incubation (other species) and colorimetric endpoint determination (10). At least 76% and usually >90% of each set of MIC determinations were within ±1 dilution of the mode MIC.