TABLE 3.

Effects of infection and antifungal treatment for mice infected with molds i.v.^a

Organism (inoculum [CFU/kg]) and treatment and dose (mg/kg)	No. of animals infected	MST ± SEM (days)	% Survivors on day 12	% Negative organs
A. flavus 01 (5 × 107)
Placebo (0)	29	7.6 ± 0.6	17	6
Amphotericin B
0.31	10	4.5 ± 0.5	0	ND
0.63	10	7.5 ± 1.0	20	ND
1.25	20	7.0 ± 0.9	35	3
2.5	20	5.5 ± 0.7	15	6
Itraconazole
2.5	10	10.7 ± 0.8	70	18
5.0	10	11.3 ± 0.5	80	10
10	10	10.9 ± 0.6	70	10
20	10	12.0 ± 0.0	100	20
A. fumigatus 10 (5 × 107)
Placebo (0)	40	10.5 ± 0.3	58	8
Amphotericin B
0.31	30	11.7 ± 0.2	90	35
0.63	30	10.4 ± 0.5	70	25
1.25	30	10.5 ± 0.5	77	28
2.5	30	11.0 ± 0.5	77	43
Itraconazole
2.5	20	10.1 ± 0.7	65	16
5.0	20	9.9 ± 0.6	50	18
10	20	11.2 ± 0.5	80	19
20	20	10.0 ± 0.9	75	18
P. boydii 24 (5 × 107)
Placebo (0)	10	9.4 ± 1.0	50	0
Amphotericin B
0.31	ND	ND	ND	ND
0.63	ND	ND	ND	ND
1.25	ND	ND	ND	ND
2.5	ND	ND	ND	ND
Itraconazole
2.5	10	10.6 ± 0.8	70	0
5.0	10	12.0 ± 0.0	100	0
10	10	12.0 ± 0.0	100	0
20	10	10.6 ± 0.7	60	0
P. boydii 24 (2 × 106)b
Placebo (0)	10	9.1 ± 1.0	40	0
Amphotericin B
0.31	10	10.8 ± 0.7	70	0
0.63	10	8.9 ± 1.2	50	0
1.25	10	10.6 ± 1.0	80	0
2.5	10	7.4 ± 0.9	20	0
Itraconazole
2.5	10	11.0 ± 0.7	80	0
5.0	10	8.6 ± 1.2	50	0
10	10	10.4 ± 0.9	70	0
20	10	9.6 ± 1.3	70	0
P. boydii 24 (4 × 106)b
Placebo (0)	10	4.2 ± 0.2	0	0
Amphotericin B
0.31	10	4.3 ± 0.2	0	0
0.63	10	4.2 ± 0.1	0	0
1.25	10	3.7 ± 0.2	0	0
2.5	10	4.0 ± 0.0	0	0
Itraconazole
2.5	10	4.3 ± 0.2	0	0
5.0	10	4.1 ± 0.1	0	0
10	10	4.4 ± 0.2	0	0
20	10	4.5 ± 0.2	0	0
P. boydii 25 (5 × 107)
Placebo (0)	10	11.0 ± 1.1	90	0
Amphotericin B
0.31	10	11.5 ± 0.5	90	0
0.63	10	11.0 ± 0.7	80	0
1.25	10	11.0 ± 0.7	80	0
2.5	10	10.3 ± 0.8	60	0
Itraconazole
2.5	ND	ND	ND	ND
5.0	ND	ND	ND	ND
10	ND	ND	ND	ND
20	ND	ND	ND	ND
P. boydii 25 (2 × 106)b
Placebo (0)	10	8.5 ± 1.2	40	0
Amphotericin B
0.31	10	10.6 ± 0.8	70	0
0.63	10	9.4 ± 1.0	50	0
1.25	10	11.9 ± 0.1	90	0
2.5	10	10.8 ± 0.7	70	0
Itraconazole
2.5	10	10.0 ± 0.8	50	0
5.0	10	7.3 ± 0.9	20	0
10	10	6.9 ± 0.3	0	0
20	10	8.7 ± 0.9	36	0
P. boydii 25 (4 × 106)b
Placebo (0)	10	3.3 ± 0.3	0	0
Amphotericin B
0.31	10	3.5 ± 0.2	0	0
0.63	10	3.4 ± 0.2	0	0
1.25	10	3.2 ± 0.2	0	0
2.5	10	3.0 ± 0.0	0	0
Itraconazole
2.5	10	3.2 ± 0.1	0	0
5.0	10	3.1 ± 0.1	0	0
10	10	3.1 ± 0.2	0	0
20	10	2.9 ± 0.1	0	0
R. arrhizus 26 (5 × 106)
Placebo (0)	20	4.9 ± 0.5	5	0
Amphotericin B
0.31	10	6.5 ± 0.8	10	0
0.63	10	7.4 ± 0.9	20	0
1.25	10	9.7 ± 0.8	40	0
2.5	10	10.9 ± 0.9	80	0
Itraconazole
2.5	10	4.3 ± 0.4	0	0
5.0	10	3.6 ± 0.2	0	0
10	10	3.7 ± 0.3	0	0
20	10	4.0 ± 0.4	0	0
R. arrhizus 27 (5 × 106)
Placebo (0)	10	5.3 ± 0.2	0	0
Amphotericin B
0.31	10	11.9 ± 0.1	90	0
0.63	10	12.0 ± 0.0	100	0
1.25	10	12.0 ± 0.0	100	0
2.5	10	12.0 ± 0.0	100	0
Itraconazole
2.5	10	4.1 ± 0.1	0	0
5.0	10	5.1 ± 0.5	0	0
10	10	4.4 ± 0.4	0	0
20	10	4.3 ± 0.3	0	0
F. oxysporum 15a (1 × 108)b
Placebo (0)	10	10.8 ± 0.9	80	0
Amphotericin B
0.31	10	8.0 ± 0.9	20	0
0.63	10	9.2 ± 0.9	30	0
1.25	10	10.8 ± 0.7	60	3
2.5	10	10.1 ± 1.0	60	0
Itraconazole
2.5	10	9.5 ± 0.9	40	0
5.0	10	10.2 ± 1.3	80	8
10	10	10.3 ± 0.9	60	10
20	10	11.2 ± 0.3	60	5
F. oxysporum 15 (1 × 108)b
Placebo (0)	10	12.0 ± 0.0	100	0
Amphotericin B
0.31	10	11.7 ± 0.3	90	0
0.63	10	11.9 ± 0.1	90	0
1.25	10	11.5 ± 0.4	80	0
2.5	10	10.6 ± 1.0	80	0
Itraconazole
2.5	10	12.0 ± 0.0	100	0
5.0	10	11.7 ± 0.3	90	0
10	10	11.7 ± 0.3	90	0
20	10	12.0 ± 0.0	100	0
F. solani 16 (1 × 108)b
Placebo (0)	10	6.7 ± 1.4	30	0
Amphotericin B
0.31	10	4.6 ± 0.4	0	0
0.63	10	6.6 ± 1.1	10	0
1.25	10	6.4 ± 0.9	0	0
2.5	10	8.1 ± 1.3	40	0
Itraconazole
2.5	10	6.6 ± 1.3	30	0
5.0	10	5.8 ± 1.2	20	0
10	10	5.5 ± 1.1	20	0
20	10	5.7 ± 1.1	20	0

^aSee footnote a of Table 2. 

^bMice were pretreated with cyclosphosphamide at 150 mg/kg i.p. before infection.