Table 1.
Clinical histories of case individuals with Stevens–Johnson syndrome after a mass drug administration campaign, Haiti, October–November 2020
| Case individual | Age (years), sex | Weight at the time of evaluation for SJS (kg) | Clinical course based on patient interviews, campaign data, and clinical reports |
|---|---|---|---|
| 1-0 | 12, M | 27 | 10/5: ingested SP 1,250/62.5 mg and PQ 11.2 mg. |
| 10/16: symptoms started with pruritus of the lips and face followed by the appearance of vesiculopapular lesions that became excoriated, and a fever developed; the rash was complicated by ulceration of the lips and oral cavity associated with throat swelling and breathing difficulties. | |||
| 10/24–11/7: admitted to a reference hospital; hospital course was uncomplicated; discharged in good condition. | |||
| 2-0 | 15, F | 43 | 10/1: ingested SP 1,500/75 mg and PQ 15 mg. |
| 10/18: symptoms started with generalized, eruptive cutaneous lesions, then ulcers appeared on the lips and oral cavity; lesions became superinfected; difficulty in breathing developed with overall deterioration. | |||
| 10/23–11/7: admitted to a reference hospital; hospital course was uncomplicated; discharged in good condition. | |||
| 3-0 | 34, F | 65 | 10/7: ingested SP 1,500/75 mg. |
| 10/7: within 24 hours symptoms started with pruritis of the tongue and lips; after 2 days, hives with skin edema (peau d’orange) developed; a home remedy of an herbal poultice was applied to the skin that aggravated the rash; ulcerations began in the mouth and lips. | |||
| 10/27: admitted to a reference hospital appearing disoriented and septic; hospital course complicated by eye pain and eyelids sticking together requiring ophthalmologic treatment; clinically stable for discharge by 11/16. Postdischarge course was complicated by the development of corneal ulcers requiring evaluation and treatment by an ophthalmologist over the following 3 months. | |||
| 4-0 | 50, F | 68 | 10/1: ingested SP 1,500/75 mg and PQ 15 mg. |
| 10/21: symptoms began with vesicles on the lips, inflammation of the face, and dysphagia for solids; excoriated papular lesions developed on the chest and left arm; the rash was complicated by a skin ulcer. | |||
| 10/5 (estimated): sought outpatient treatment at a local health center; by 11/1 overall improvement with lip ulcers and skin lesions healing. |
F = female; M = male; PQ = primaquine; SJS = Stevens–Johnson syndrome; SP = sulfadoxine-pyrimethamine. SP: target dose of 25/1.25–33/1.7 mg/kg; maximum 1,500/75 mg; PQ: target dose of 0.25 mg/kg; maximum 15 mg.