Table 2:

Univariable and multivariable analysis of factors related to non-small-cell lung cancer-specific survival with a sub-distribution, hazard-function, competing risk model among people who have ever smoked

	Univariable analysis		Multivariable analysis*
	Crude HR (95% CI)	p value	Adjusted HR (95% CI)	p value
Age at diagnosis (>65 years vs ≤65 years)	0.99 (0.94–1.04)	0.74	1.14 (1.08–1.22)	<0.0001
Sex (female vs male)	0.83 (0.79–0.88)	<0.0001	0.91 (0.85–0.98)	0.0085
Ethnicity
Black vs White	0.91 (0.85–0.98)	0.015	1.02 (0.90–1.15)	0.78
Asian vs White	1.06 (0.98–1.14)	0.14	1.07 (0.85–1.35)	0.56
Other or missing vs White	1.10 (0.87–1.38)	0.44	0.84 (0.64–1.11)	0.22
Education
More education vs less education	0.67 (0.62–0.72)	<0.0001	0.90 (0.80–1.00)	0.043
Moderate education vs less education	0.71 (0.66–0.76)	<0.0001	0.90 (0.81–0.99)	0.030
Other or missing vs less education	0.87 (0.80–0.95)	0.0011	1.03 (0.86–1.24)	0.73
Clinical stage at diagnosis
2 or 3A vs 1	2.43 (2.25–2.63)	<0.0001	2.38 (2.20–2.58)	<0.0001
3B or 4 vs 1	5.51 (5.14–5.92)	<0.0001	5.55 (5.15–5.98)	<0.0001
Histology
Squamous cell vs adenocarcinoma	1.12 (1.05–1.19)	0.0003	1.11 (1.04–1.19)	0.0022
Large cell or other vs adenocarcinoma	1.41 (1.33–1.51)	<0.0001	1.19 (1.10–1.28)	<0.0001
Time cohort (per increase in 10 years of diagnosis date)	0.96 (0.92–1.01)	0.15	0.93 (0.85–1.01)	0.077
Pack years (>40 vs ≤40)	1.07 (1.02–1.13)	0.0095	1.01 (0.95–1.07)	0.74
Smoking-abstinence duration at diacnosis
<1 year (ie, current smokers)	1 (ref)	..	1 (ref)	..
1–3 years	0.80 (0.74–0.86)	<0.0001	0.94 (0.87–1.02)	0.15
>3–5 years	0.82 (0.71–0.94)	0.0041	0.91 (0.79–1.05)	0.21
>5 years	0.72 (0.68–0.77)	<0.0001	0.87 (0.81–0.93)	0.0001

HR=hazard ratio.

^*As well as the variables listed, we also adjusted for individual studies.