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. 2023 Sep 14;9(9):1835–1845. doi: 10.1021/acscentsci.3c00625

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© 2023 The Authors. Published by American Chemical Society

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XCR1-targeted intracellular delivery outperforms nontargeted constructs. (A) Mice were s.c. vaccinated with LF_N-OVA (30 pmol, OVA_252–270) and c-di-GMP (25 μg), which were coadministered with mPAC, PA, or scFv-mPAC (6 pmol). (B) IFN-γ enzyme-linked immunosorbent spot (ELISpot) data are shown from 7 days after the boost (mean ± SEM; n = 10 mice per group). Statistical significance was calculated using a one-way ANOVA with the Fisher’s Least Significant Difference test. Data are compiled from two independent experiments.