FIG. 5.

Mean ± SD urinary excretion of drug over 24 h on day 1 (open columns) and on day 8 (hatched columns) of oral dosing with foscarnet. Patients received the drug at dosages of 90 mg/kg QD (n = 6), 90 mg/kg BID (n = 6), and 180 mg/kg QD (n = 3). Two patients, both of whom were in the 90-mg/kg BID group, withdrew from the study, and data for day 8 were not available for these patients. Urinary excretion of the drug was higher on day 8 than on day 1 ∗, P < 0.05; ∗∗∗, P < 0.001 (day 8 versus day 1).