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. 2023 Sep 15;14:1240736. doi: 10.3389/fphar.2023.1240736

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Copyright © 2023 Kuang, Zheng, Ma, Zeng, Wu, Weng and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of LAG3 Knockdown on A549 Cells. (A–C) Expression of LAG3 in A549 cells after si-LAG3 treatment assessed by qPCR and Western blot. (D) CCK8 assay showing the inhibition of A549 cell proliferation after LAG3 knockdown. (E, F) Transwell migration assay demonstrating the inhibitory effect of LAG3 suppression on A549 cell migration. (G, H) Scratch wound healing assay corroborating the inhibitory effect of LAG3 suppression on A549 cell migration. (I, J) Fluorescence microscopy images of EDU/DAPI stained A549 cells showing reduced red fluorescence intensity, indicative of inhibited cell proliferation, after si-LAG3 treatment. *p < 0.05, **p < 0.01, ***p < 0.001.