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. 2023 Sep 28;23:220. doi: 10.1186/s12935-023-03050-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — MYH9 enhances cell proliferation and resistance to temozolomide. (A, B) MYH9 expression was measured by RT-PCR assays and western blot in U87 and LN229 cells transfected with shNC ,shMYH9-1 and shMYH9-2. GAPDH was used as a loading control. (C) MYH9 protein level was measured by western blot in U87 and LN229 cells transfected with siNC or siMYH9. GAPDH was used as a loading control. CCK8 assay (D), EdU incorporation assay (E), clone formation assay (F) after MYH9 knockdown. (G) Dose-response curves of U87 and LN229 treated with siMYH9 and siNC respectively following treatment with temazolamide for 48 h. Data are presented as the mean ± SD for three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001