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. 2023 Sep 29;24:237. doi: 10.1186/s12931-023-02528-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The overall transcriptomes characteristics between the control and stretch groups. (a) The PCA plot of transcriptome profiling. (b) Heat maps of mRNA (|log2FC| >0.58 and FDR < 0.05). Red and blue indicate up- and downregulation, respectively. (c) Histogram of differentially expressed genes (DEGs) expression between the control and stretch groups. (d) The volcano analysis of DEGs with color-coded. The x-axis represented the log2 of fold change (FC) and the y-axis represented log10 of p values. Blue dots were downregulated genes and red dots were upregulated genes. The leftover black dots were the genes without significant differences. The top 15 enrichment GO of differentially expressed genes. All GO terms were divided into three ontologies: yellow, biological process (e); blue, molecular function (f), and red, cellular component (g). The top 15 KEGG pathway terms (h) of differentially expressed genes