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The annual trend in the number of published clinical trials between 1970 and 2022 was examined in four leading general medical journals. The results revealed a significant increase in the number of published trials for NEJM and JAMA, whereas no significant change was observed for Lancet and BMJ over this period (Cochrane Armitage test, p for trend < 0.001). In the most recent decade (2013–2022), JAMA published a total of 75 trials, whereas BMJ published only 7 trials
