Table 1.

CDR1–3 and hallmark (HM) sequences of immunized llama WT or humanized VHH libraries (FERF or VGLW) that were selected for production and experimental profiling (shown in Table 3). Residues that are different from the most potent sequences within each CDR3 sequence cluster are shown in orange; susceptible chemical liability and post-translational modification motifs (DG, NG, M, unpaired C, and NXS/T) are indicated as red boxes.