Table 2.

Markers significantly associated with OS benefit under immune checkpoint inhibitors. HR = Hazard ratio; 95% CI = 95% confidence interval.

Markers associated with OS benefit
Compartment	Marker	Cut-off point	Log-rank HR (95% CI)	P	Univariable HR (95% CI)	P	Multivariable HR (95% CI)	P
CD68	ERK1/2	Median	0.39 (0.15–0.98)	.043	0.36 (0.13–1.01)	.042	0.24 (0.07–0.77)	.012
	ERK1/2	Top tertile	.32 (.12–.82)	0.052	.31 (.09–1.08)	0.039	.14 (.03–.74)	0.0079
	HLA-DR	Median	.26 (.10–.67)	0.0048	.22 (.07–.70)	0.0045	.09 (.01–.55)	0.0035
	HLA-DR	Top tertile	.30 (.12–.76)	0.039	.29 (.08–1.01)	0.028	.22 (.05–1.02)	0.037
	HLA-DR	Top quartile	.12 (.04–.30)	0.010	.12 (.02–.89)	0.010	.11 (.01–1.18)	0.019
CD45	PD-1	Median	2.95 (1.10–7.94)	.033	3.01 (1.04–8.73)	.034	1.93 (0.49–7.54)	.34
	LAG3	Median	3.00 (1.11–8.08)	0.032	3.02 (1.05–8.73)	0.032	3.02 (.65–13.94)	0.14
	MART1	Median	2.75 (1.03–7.38)	0.047	2.82 (.97–8.19)	0.047	1.77 (.50–6.28)	0.37
	OX40L	Top tertile	3.07 (.98–9.59)	0.016	3.28 1.18–9.11)	0.025	5.83 (1.71–19.84)	0.0046
	BCL6	Top quartile	2.61 (.74–9.16)	0.049	2.75 (.96–7.85)	0.072	3.20 (.88–11.7)	0.087
CD45+CD68	BIM	Top quartile	2.70 (0.96–7.61)	.020	1.99 (0.81–4.87)	.14	1.18 (0.40–3.53)	.8

Bold values represent the Values equal or below 0.05.