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Complement-mediated acute glomerulonephritis and pulmonary hemorrhage. In the human glomerular basement membrane (GBM), the non-collagenous domain of the α3 chain of type IV collagen binds to self-anti-GBM antibodies, forming immune complexes and activating the complement system in situ. This triggers the recruitment of immune cells to attack the GBM and alveolar basement membrane, leading to the development of acute glomerulonephritis and pulmonary hemorrhage syndrome.
