TABLE 1.
Activities of 12 antimicrobial agents against M. tuberculosis H37Ra and H37Ra gfp determined with the BACTEC 460 system and by GFPMA
| Drug | MIC (μg/ml)a
|
MBC (μg/ml)b for H37Ra gfp | ||
|---|---|---|---|---|
| BACTEC 460 system
|
GFPMA with H37Ra gfp | |||
| H37Ra | H37Ra gfp | |||
| Rifampin | 0.025 | 0.0125 | 0.003–0.006 | 0.0125 |
| Isoniazid | 0.05 | 0.0125–0.05 | 0.0125–0.05 | 0.0125 |
| Capreomycin | 2.5 | 2.5 | 2.5 | 5.0 |
| Ofloxacin | 1.0 | 1.0–2.0 | 0.5–1.0 | 0.5 |
| Cycloserine | 50 | 50 | 1.56–3.25c | >50 |
| Clarithromycin | 1.0 | 0.5–2.0 | 0.5–32 | 16 |
| Amikacin | 2.5 | 2.5 | 2.5 | >5.0 |
| Ethambutol | 1.88 | 1.88 | 1.88 | 7.5 |
| Thiacetazone | <0.01 | <0.01 | <0.01–0.03 | >2.0 |
| Ethionamide | 1.25 | 1.25 | 0.313–0.63c | 0.63 |
| Streptomycin | 1.5 | 1.5 | 0.75–1.5 | 3.0 |
| Kanamycin | 2.5 | >5.0 | >5.0 | >5.0 |
a
Results are ranges for three experiments.
b
Results are those of a single representative experiment in which the numbers of CFU of H37Ra gfp were determined.
c
Significantly different (P < 0.05) from the MIC for H37Ra gfp determined with the BACTEC 460 system.