Table 2.
Sensitivity, specificity, accuracy, and receiver operating characteristics (ROC) area under the curve (AUC) for prediction of non-pCR for manual dynamic contrast-enhanced MRI (DCE), three-component Restriction Spectrum Imaging model (RSI3C) classifier and the mean apparent diffusion coefficient (ADC) after all neoadjuvant therapy prior to surgical intervention (post-Tx time point).
| DCE | RSI3C classifier | ADC | |
|---|---|---|---|
| Threshold value | 0.60 cm | 0.75 cm | 1.5 × 10-3 mm2/s |
| Sensitivity (95% CI) Post-Tx | 0.88 (0.64-0.99) | 0.71 (0.44-0.90) | 0.76 (0.50-0.93) |
| Specificity (95% CI) Post-Tx | 0.70 (0.35-0.93) | 0.90 (0.56-1.00) | 0.50 (0.19-0.81) |
| Accuracy (95% CI) Post-Tx | 0.81 (0.61-0.94) | 0.78 (0.58-0.91) | 0.67 (0.46-0.83) |
| ROC AUC | 0.79 | 0.80 | 0.52 |
pCR, pathological complete response; Tx, treatment. For context, the longest diameter at pre-Tx was on average 4.9 cm (+/- 2.5) for DCE and 3.6 cm (+/- 1.7) for RSI3C. Mean ADC at pre-Tx was 1.1 × 10-3 mm2/s (+/- 0.3 × 10-3).