Table 2.
Outcomes by HRF/PH severity category.
| Mild (0–5) N = 5 | Moderate (6–10) N = 65 | Severe (11–15) N = 13 | p value | |
|---|---|---|---|---|
| Dichotomous outcomes, N (%) | ||||
| Death/ECLS | 0 | 12 (18) | 10 (77) | <0.0001 |
| Required ECLS | 0 | 8 (12) | 8 (62) | <0.001 |
| Died before discharge | 0 | 7 (11) | 7 (54) | <0.001 |
| Required iNO | 1 (20) | 50 (77) | 13 (100) | <0.01 |
| Required vasoactive infusions | 0 | 42 (65) | 13 (100) | <0.0001 |
| Required IMV | 1 (20) | 49 (75) | 13 (100) | <0.01 |
| Required HFOV | 0 | 41 (84) | 13 (100) | 0.03 |
| Ventilated week or longera | 0 | 21/42 (50) | 3/6 (50) | 0.72 |
| Ventilated 2 weeks or longera | 0 | 7/42 (17) | 3/6 (50) | 0.13 |
| LOS over a weeka | 4/5 (80) | 53/58 (91) | 6/6 (100) | 0.31 |
| Continuous outcomesb, median (IQR) | ||||
| Duration of iNO, hoursa | 8 (8–8) | 86 (57–158) | 120 (58–242) | 0.27 |
| Duration of IMV, daysa | 1 (1–1) | 6.5 (4–11) | 9 (4–16) | 0.27 |
| Total length of stay, daysa,b | 16 (13–23) | 19 (11–33) | 32.5 (16–76) | 0.95 |
| ICU length of stay, daysa | 16 (13–23) | 19 (11–733) | 32.5 (16–51) | 0.93 |
| VIS score | – | 14.5 (9–27.5) | 25 (15–1745) | 0.17 |
| Duration ECLS, hoursa | – | 106 (96–162) | 152 (86–278) | 0.69 |
iNO inhaled nitric oxide. ECLS extracorporeal life support. IMV invasive mechanical ventilation. HFOV high frequency oscillatory ventilation. VIS vasoactive-isotropic score. IQR interquartile range.
aExcludes patients that died so the denominator shown when relevant.
bp values are from linear regression comparing outcomes as continuous variables across the score categories.
Bold values indicate statistical significance.