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. 2023 Sep 30;14(9):644. doi: 10.1038/s41419-023-06165-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Visualization of a t-test in form of a volcano plot comparing normal to p53 lesion (proteins with p < 0.05 in red.) B Hierarchical clustering of the significant variable proteins between normal tissue and p53 signature (t-test with p < 0.05), C IHC of p53, STIL and STIC lesions with anti-FBLN5 and anti-Emilin2 antibodies, the arrow shows the p53 lesion on the tissue. The graphs represent the quantification of the fluorescence intensity of each marker in the corresponding tissue relative to the fluorescence intensity in the normal FTE.