Table 1.
a: Description of clinical characteristics of patients with a preneoplastic lesion in the fallopian tube fimbria (prospective cohort). b: Description of clinical characteristics of patients with a preneoplastic lesion in the fallopian tube fimbria (validation cohort).
| Case ID | Lesions sampled | BRCA status | Age at diagnosis | Location in fimbria | Ovary lesion | Other lesions | Personal history of breast cancer | Other remarks |
|---|---|---|---|---|---|---|---|---|
| a | ||||||||
| 1 | Normal, p53 signature | BRCA1 | 40 | Right | No | SCOUT in tube | No | Left ovarian theca cyst |
| 2 | Normal, p53 signature | BRCA1 | 39 | Right and left | No | No | Yes | |
| 3 | STIL (x3) | unknown | 61 | Left | No | No | No | Uterus Leiomyoma |
| 4 | STIC (x3) | BRCA1 | 36 | Right and left | No | Several p53 signature | No | HGSC in the left tube |
| 5 | Normal, p53 signature | Family history | 38 | Left | No | No | No | |
| 6 | STIL, STIC | BRCA1 | 48 | Left | No | Several p53 signature | Yes | |
| 7 | Normal, p53 signature | BRCA1 | 35 | Left | No | Several p53 signature | Yes | HGSC in the left fimbria |
| 8 | Patient 8 shows an ovarian high-grade serous carcinoma with no evidence of pre-neoplastic lesion in the fallopian tube. The BRCA status is unknown. | |||||||
| b | ||||||||
| F1 | STIL | BRCA2 | 65 | Left | No | No | ||
| F2 | Normal, p53 signature | BRCA1 | 38 | Right | No | No | Yes | |
| F3 | STIC | BRCA1 | 37 | Right | No | STIL to the left fimbria | Yes | HGSC in the left tube |
| F4 | Normal, p53 signature | unknown | 50 | Left | No | No | No | Follicular cyst in the ovary |
| F5 | Normal, p53 signature | BRCA2 | 50 | Both sides | No | No | Lesion in the breast | |
| F6 | STIC | BRCA1 | 41 | Right | No | No | No | cyst in the left ovary |
| F7 | Normal, p53 signature | No | 45 | Right | No | HGSC in the left tube | Family breast and ovarian cancer | |
| F8 | Normal, p53 signature | BRCA2 | 67 | Left | No | No | No | |
| F9 | Normal, p53 signature | BRCA1 | 70 | Both sides | No | No | No | |
| F10 | STIL, STIC | BRCA1 | 62 | Both sides | HGSC in both ovaries | No | No | |
| F11 | STIC | BRCA1 | 44 | Right | No | No | Yes | |
| F12 | Normal, p53 signature | No | 68 | Right | No | No | No | |
| F13 | Normal, p53 signature | unknown | 62 | Right | Brenner tumor in right ovary | No | Yes | |
| F14 | STIC | BRCA1 | 44 | Right | No | HGSC in the right chorion | Yes | |
| F15 | Normal, p53 signature | BRCA2 | 46 | Left | No | No | No | |
| F16 | Normal, p53 signature | BRCA2 | 50 | Left | No | No | Yes | |
| F17 | STIC | BRCA1 | 44 | Right | No | No | No | |
| F18 | STIL | BRCA2 | 49 | Left | No | No | No | |
| F19 | Normal, p53 signature | BRCA2 | 43 | Right | No | No | No | |
| F20 | Normal, p53 signature | unknown | 51 | Right | No | No | Yes | Family breast and ovary cancers |
| F21 | Normal, p53 signature | BRCA2 | 41 | Right | No | No | No | |
| F22 | STIL | BRCA1 | 58 | Right | No | No | Yes | |
| F23 | Normal, p53 signature | BRCA1 | 60 | Left | No | HGSC in the right tube | Yes | |
| F24 | STIC | BRCA1 | 42 | Right | No | No | Yes | |
| F25 | STIC, STIL | BRCA1 | 68 | Both sides | No | No | No | |
| F26 | STIL | BRCA1 | 66 | Left | No | No | Yes | |
| F27 | STIL, STIC | unknown | 35 | Both sides | No | HGSC in the left tube | Yes | |