TABLE 1.
Analysis of liver histology in experimentally infected ducklings undergoing l-FMAU or ddC therapy
| Treatment protocol and duck no. | Hepatocyte aspecta | Portal inflammationb | Lobular inflammationb | Cell necrosis, Councilman bodiesb |
|---|---|---|---|---|
| Controls | Ballooning degeneration | |||
| 522 | + | ++ | ++ | + |
| 524 | + | ++ | ++ | ± |
| 525 | + | +++ | + | ± |
| 529 | + | ++ | + | − |
| ddC | Microvesicular steatosis | |||
| 549 | + | + | − | + |
| 551 | − (subnormal) | − | − | ± |
| 553 | + | ± | ++ | − |
| 554 | + | − | − | + |
| l-FMAU at 20 mg/kg twice a day | ||||
| 534 | Ballooning degeneration (±) | ++ | − | − |
| 537 | Macrovesicular steatosis | + | − | − |
| 538 | Subnormal | ± | − | +++ |
| 539 | Macrovesicular steatosis | ++ | + | − |
| l-FMAU at 40 mg/kg once a day | Ballooning degeneration | |||
| 530 | + | + | + | − |
| 531 | ± | ++ | + | − |
| 532 | + | ± | − | − |
| 533 | + | − | − | − |
| l-FMAU at 80 mg/kg every other day | ||||
| 540 | Macrovesicular steatosis | ++ | + | − |
| 541 | Ballooning degeneration | ++ | + | − |
| 543 | Ballooning degeneration | ++ | + | − |
| 546 | Ballooning degeneration | ++ | + | − |
a
For hepatocyte aspect (ballooning degeneration and microvesicular steatosis), plus signs indicate the presence of one given histological pattern and minus signs indicate its absence. ± indicates that the histological change was observed in only a few cells.
b
For portal inflammation, lobular inflammation, cell necrosis, and Councilman bodies, + indicates a minimal degree of the given histological lesion, ++ indicates a mild degree, and +++ indicates a moderate degree.