Table 6.
Item coverage in identified PROs cross-referenced with issues identified by at least 2 participants in a qualitative study exploring experiences of CAR-T [31]
| PRO | Physical function | Emotional function | Role function | Social function | Fatigue | Pain | Cognitive | Sleep | Appetite | Headache | Chills/cold | Light headedness | Swelling | Bowel issues | Nausea/vomiting | Shaking hands | Coughing |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SF-36 Health Survey (SF-36) (Brazier et al., 1992) [50] | X | X | X | X | X | X | |||||||||||
| Patient-Reported Outcome Measurement Information System-29 (PROMIS-29) (Hays et al., 2018) [48] | X | X | X | X | X | X | X | ||||||||||
| Patient-Reported Outcomes-Common Terminology Criteria for Adverse Events (PRO-CTCAE) (Dueck et al., 2015) [51] | X | X | X | X | X | X | X | X | X | X | X | X | X | ||||
| Inventory of Depression and Anxiety Symptoms (IDAS) (Watson et al., 2007) [52] | X | ||||||||||||||||
| Brief Pain Inventory (BPI) (C. Cleeland & Ryan, 1994) [53] | X | X | X | X | X | X | |||||||||||
| Fatigue Severity Index (FSI) | X | ||||||||||||||||
| Pittsburgh Sleep Quality Index (PSQI) (Buysse et al., 1989) [54] | X | X | X | X | X | X | |||||||||||
| Simplified QoL questionnaire | X | X | X | ||||||||||||||
| European Organisation for Research and Treatment of Cancer Quality of Life Core 30 (EORTC QLQ-C30) (Aaronson et al., 1993) [55] | X | X | X | X | X | X | X | X | X | X | X | ||||||
| European Organisation for Research and Treatment of Cancer Multiple Myeloma (EORTC MY20) | X | X | X | X | X | X | X | X | X | X | X | ||||||
| EuroQoL 5D (EQ-5D-5L) (Herdman et al., 2011) [56] | X | X | X | X | X | ||||||||||||
| EuroQoL 5D EQ-5D-3L (Rabin & De Charro, 2001) [57] | X | X | X | X | X | ||||||||||||
| EuroQoL 5D Youth (EQ-5D-Y) (Wille et al., 2010) [58] | X | X | X | X | X | ||||||||||||
| Patient-Reported Outcome Measurement Information System Global Health (PROMIS Global Health) (Hays et al., 2009) [59] | X | X | X | X | X | X | |||||||||||
| PROMIS Cognitive Function (Mullane) | x | ||||||||||||||||
| Additional questions | |||||||||||||||||
| MD Anderson Symptom Inventory (MDASI) (C. S. Cleeland et al., 2000) [60] | x | x | x | x | x | x | x | ||||||||||
| Single-item HRQOL | |||||||||||||||||
| CAR T-cell therapy-specific symptoms | x | x | x | x | x | x | x | x | x | ||||||||
| The Pediatric Quality-of-Life Inventory (PedsQL) (Alderfer & Marsac, 2013) [61] | x | x | x | x | |||||||||||||
| Functional Assessment Cancer Therapy-General (FACT-G) (Cella et al., 1993) [62] | x | x | x | x | x | x | x | x | |||||||||
| Quality-of-Life in Neurological Disorders (Neuro-QoL v2) (Gershon et al., 2012) [63] | x | ||||||||||||||||
| Functional Assessment of Cancer Therapy (FACT-Lym) (Hlubocky et al., 2013) [64] | x | x | x | x | x | x | x | x | x | x |