TABLE 1.
In vivo and in vitro efficacies of azithromycin and erythromycin against four S. pneumoniae strains
| Strain/serotype | MIC (μg/ml)
|
ED50 (mg/kg) (95% CI)a
|
Generation time (min) in MHB in vitro | |||
|---|---|---|---|---|---|---|
| Azithromycin | Erythromycin | Penicillin | Azithromycin | Erythromycin | ||
| 68040/6B | 0.03 | 0.03 | 0.016 | 1.83 (0.34–4.90) | 3.75 (1.27–8.28) | 53 |
| 964/14 | 0.03 | 0.03 | 0.25 | 3.87 (1.49–8.10) | 3.48 (0.54–13.55) | 44 |
| 999/19A | 0.03 | 0.03 | 0.5 | 6.22 (2.95–12.97) | 4.15 (1.18–10.51) | 31 |
| 1064/6B | 0.03 | 0.03 | 0.25 | 4.84 (4.84–4.84) | 2.15 (0.37–6.04) | 31 |
a
ED50s were determined in mice. CI, confidence interval.