TABLE 3.
Bacterial counts at t = 24 h and survival of mice during one experiment using different azithromycin dosing regimens
| No. of dosesa | Log median blood CFU count (range) | Log median peritoneal CFU count (range) | No. of mice dead/total (%) within 6 days |
|---|---|---|---|
| 0 (control) | 4.23 (1.70–7.43) | 6.68 (5.38–11.11) | 10/10 (37.5) |
| 1 | 4.10 (3.23–6.89) | 7.26 (6.99–8.95) | 10/25 (40) |
| 2 | 1.70 (1.70–2.35) | 4.38 (1.11–5.75) | 9/24 (37.5) |
| 4 | 3.72 (1.88–4.94) | 6.58 (2.77–7.70) | 14/25 (56) |
| 8 | 3.80 (3.04–5.18) | 9.88 (5.78–9.95) | 16/25 (64) |
a
The total amount of azithromycin administered in each case was 4 mg/kg.