Table 1.
Characteristic of participants
| Variable | Total (n = 3251) | Lower NLR (n = 2784) | Higher NLR (n = 467) | P value |
|---|---|---|---|---|
| Age, years | 59.59 (58.94,60.25) | 58.64 (57.95,59.34) | 64.62 (63.23,66.00) | < 0.0001 |
| Sex, % | 0.11 | |||
| Female | 49.44 (45.38,53.51) | 50.36 (47.76,52.95) | 44.61 (38.39,50.84) | |
| Male | 50.56 (45.90,55.22) | 49.64 (47.05,52.24) | 55.39 (49.16,61.61) | |
| Race, % | < 0.0001 | |||
| Non-Hispanic Black | 13.19 (11.47,14.92) | 14.63 (12.39,16.87) | 5.59 (3.63,7.56) | |
| Mexican American | 8.96 (7.19,10.73) | 9.82 (7.73,11.90) | 4.44 (2.16,6.71) | |
| Non-Hispanic White | 65.54 (57.71,73.37) | 62.49 (58.58,66.40) | 81.67 (77.21,86.14) | |
| Others | 12.30 (10.52,14.09) | 13.06 (10.99,15.14) | 8.30 (5.92,10.67) | |
| BMI, kg/m2 | 32.29 (31.92,32.65) | 32.45 (32.10,32.80) | 31.43 (30.36,32.49) | 0.06 |
| BMI category, % | 0.03 | |||
| Normal weight (< 25) | 13.87 (11.98,15.76) | 13.34 (11.59,15.09) | 18.43 (14.04,22.81) | |
| Over weight (25–30) | 27.93 (25.07,30.79) | 27.95 (25.75,30.14) | 31.35 (24.61,38.09) | |
| Obesity (≥ 30) | 56.24 (51.32,61.17) | 58.71 (56.16,61.26) | 50.22 (43.76,56.68) | |
| Smoking status, % | 0.09 | |||
| Never | 49.63 (46.00,53.27) | 50.95 (48.28,53.62) | 43.64 (36.98,50.30) | |
| Former | 33.02 (29.15,36.89) | 31.99 (29.47,34.51) | 39.07 (32.63,45.51) | |
| Current | 17.04 (14.91,19.18) | 17.06 (15.07,19.05) | 17.29 (12.71,21.87) | |
| Drinking status, % | 0.61 | |||
| Never | 15.89 (13.85,17.92) | 17.09 (15.00,19.18) | 16.64 (12.26,21.03) | |
| Former | 23.65 (20.76,26.53) | 24.80 (22.44,27.17) | 28.16 (22.60,33.72) | |
| Mild | 30.80 (27.26,34.33) | 32.78 (29.79,35.76) | 34.15 (27.47,40.83) | |
| Moderate | 11.07 (9.05,13.09) | 12.13 (9.88,14.39) | 10.40 (6.39,14.41) | |
| Heavy | 11.94 (10.09,13.79) | 13.20 (11.36,15.03) | 10.64 (7.04,14.25) | |
| Hypertension, % | 0.06 | |||
| No | 31.37 (27.86,34.88) | 32.38 (29.66,35.10) | 26.08 (20.29,31.87) | |
| Yes | 68.60 (63.01,74.19) | 67.62 (64.90,70.34) | 73.92 (68.13,79.71) | |
| NLR | 2.49 (2.43,2.55) | 2.05 (2.02,2.08) | 4.80 (4.61,4.98) | < 0.0001 |
| WBC, × 109/L | 7.37 (7.27,7.47) | 7.14 (7.04,7.24) | 8.60 (8.23,8.96) | < 0.0001 |
| Neutrophil, × 109/L | 4.51 (4.43,4.59) | 4.17 (4.10,4.24) | 6.34 (6.04,6.63) | < 0.0001 |
| Lymphocyte, × 109/L | 2.03 (1.99,2.06) | 2.15 (2.11,2.18) | 1.39 (1.33,1.45) | < 0.0001 |
| Platelet, × 109/L | 243.04 (239.66,246.42) | 244.05 (240.43,247.67) | 237.74 (227.51,247.97) | 0.27 |
| Scr, umol/L | 85.24 (82.92,87.57) | 83.07 (80.78, 85.36) | 96.73 (89.91,103.55) | < 0.001 |
| BUN, mmol/L | 5.58 (5.48,5.69) | 5.39 (5.28,5.50) | 6.62 (6.28,6.96) | < 0.0001 |
| eGFR, mL/min/1.73m2 | 84.03 (82.97,85.09) | 85.80 (84.63,86.97) | 74.67 (72.20,77.13) | < 0.0001 |
| HbA1c, % | 6.91 (6.84,6.98) | 6.96 (6.88,7.04) | 6.64 (6.45,6.83) | 0.003 |
| HDL, mmol/L | 1.30 (1.28,1.32) | 1.29 (1.27,1.31) | 1.37(1.28,1.46) | 0.1 |
| LDL, mmol/L | 2.77 (2.73,2.82) | 2.80 (2.75,2.85) | 2.61 (2.52,2.71) | 0.001 |
| TG, mmol/L | 1.67 (1.62,1.72) | 1.71 (1.66,1.76) | 1.46 (1.38,1.54) | < 0.0001 |
| TC, mmol/L | 4.84 (4.78,4.89) | 4.87 (4.82,4.93) | 4.65 (4.51,4.80) | 0.005 |
| Education levels, % | 0.47 | |||
| Less than high school | 10.72 (9.26,12.19) | 10.82 (9.34,12.30) | 10.19 (6.90,13.49) | |
| High school or equivalent | 40.28 (35.95,44.61) | 39.76 (36.56,42.95) | 43.03 (36.71,49.36) | |
| College or above | 48.94 (44.23,53.64) | 49.38 (46.14,52.61) | 46.60 (40.74,52.47) | |
| Not recorded | 0.07 (0.02, 0.12) | 0.05 (0.00,0.10) | 0.17 (− 0.02,0.36) | |
| Family income-poverty ratio, % | 0.85 | |||
| ≤ 1.0 | 14.47 (12.89,16.05) | 14.72 (12.99,16.45) | 13.15 (9.98,16.32) | |
| 1.0–3.0 | 39.24 (35.16,43.32) | 38.93 (36.14,41.72) | 40.87 (34.80,46.94) | |
| > 3.0 | 39.03 (34.76,43.29) | 39.12 (36.04,42.19) | 38.57 (31.86,45.27) | |
| Not recorded | 7.26 (5.94, 8.59) | 7.23 (5.83, 8.63) | 7.41 (4.79,10.04) | |
Continuos variables are presented as the mean and 95% confidence interval, category variables are described as the percentage and 95% confidence interval