Table 8.
Summary of the results of the forced degradation study of MIR and TAM under various conditions
| Forced degradation conditions | % Recovered | Rf of degradation products | ||
|---|---|---|---|---|
| MIR | TAM | MIR | TAM | |
| Alkaline | 90 | 63 | Not detected | 0.22, 0.27, 0.29, 0.32, 0.5, 0.53, 0.56 |
| Acidic | 88 | 64 | Not detected | 0.23 |
| Oxidative | 75 | 72 | 0.89 | 0.22, 0.25, 0.56 |
| Thermal | 76 | 82 | Not detected | 0.22, 0.25, 0.27 |
| Photolytic | Stable | 95 | stable | 0.23 |
Related to MIR, the result of the stress degradation study is matched with the previous published article. MIR showed degradation under acidic, basic, hydrolytic and oxidative stress conditions but stable in photolytic condition [11]. While TAM showed degradation under acidic, basic, hydrolytic, photolytic and oxidative stress conditions [29]