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. 2023 Sep 30;17(1):130. doi: 10.1186/s13065-023-01043-9

Table 8.

Summary of the results of the forced degradation study of MIR and TAM under various conditions

Forced degradation conditions % Recovered Rf of degradation products
MIR TAM MIR TAM
Alkaline 90 63 Not detected 0.22, 0.27, 0.29, 0.32, 0.5, 0.53, 0.56
Acidic 88 64 Not detected 0.23
Oxidative 75 72 0.89 0.22, 0.25, 0.56
Thermal 76 82 Not detected 0.22, 0.25, 0.27
Photolytic Stable 95 stable 0.23

Related to MIR, the result of the stress degradation study is matched with the previous published article. MIR showed degradation under acidic, basic, hydrolytic and oxidative stress conditions but stable in photolytic condition [11]. While TAM showed degradation under acidic, basic, hydrolytic, photolytic and oxidative stress conditions [29]