Table 3.

Glutathione (GSH) and 8-Hydroxy-2-Deoxyguanosine (8-OH2dG) Levels in Retina After Repeated VEH, NCX 470, LUM, or BIM in ET-1-Treated Eyes

Group ID	Dose (% w/w)	GSH (µmol/mg Protein)	8-OH2dG (pg/µg DNA)
Naïve	–	1.30 ± 0.04 (n = 4)	18.9 ± 0.7 (n = 3)
VEH	–	0.37 ± 0.04a (n = 6)	57.5 ± 6.3a (n = 6)
NCX 470	0.1	1.31 ± 0.25b (n = 6)	34.1 ± 5.0b,c (n = 6)
LUM	0.01	1.09 ± 0.07b (n = 4)	51.8 ± 3.5 (n = 5)
BIM	0.072	1.39 ± 0.23b (n = 4)	41.5 ± 1.9 (n = 6)

GSH and 8-OH2dG levels in naïve eyes or at week 6 in eyes treated with VEH, NCX 470, LUM, and BIM. Data are mean ± SEM, multiple t-test with Welch correction.

^a p < 0.05 versus naïve.

^b p < 0.05 versus vehicle.

^c p < 0.05 versus LUM or BIM.