. 2023 Sep 28;37(5):355–366. doi: 10.7555/JBR.37.20230022

Table 2. IC ₅₀s of gemcitabine and GEM-ZZQ for different lung cancer cell lines .

Cell lines	GEM IC ₅₀ (μmol/L) ^a	GEM-ZZQ IC ₅₀ (μmol/L) ^a	Fold change ^b
Student's t-test was used to test the differences between the two groups. ^* P < 0.05. ^aData are presented as mean ± standard deviation, n = 3. ^bFold change = IC ₅₀ (GEM-ZZQ)/IC ₅₀ GEM. GEM indicates gemcitabine. GEM-ZZQ indicates the prodrug with an H ₂O ₂-sensitive thiazolidinone moiety at the 4th amino group of GEM.
H1975	0.010±0.001	0.014±0.004	1.400
HCC827 ^*	1. 544±0.069	2.136±0.120	1.383
H1299 ^*	0.470±0.047	0.567±0.014	1.206
H157 ^*	0.451±0.055	1.061±0.087	2.353
H460 ^*	0.001±0.000	0.004±0.000	3.909

Table 2. IC 50s of gemcitabine and GEM-ZZQ for different lung cancer cell lines .