Table 3. IC 50s of cisplatin when it was administrated in combination with GEM and GEM-ZZQ in H1299 cell lines .
| GEM/
GEM-ZZQ (μmol/L) |
Combined GEM
(μg/mL) a |
Combined
GEM-ZZQ (μg/mL) a |
Fold
change |
|
Student's t-test was used to test the differences between the two groups. aData are presented as mean ± standard deviation, n = 3. Fold change = IC 50 (GEM-ZZQ)/IC 50 (GEM). GEM-ZZQ indicates the prodrug with an H 2O 2-sensitive thiazolidinone moiety at the 4th amino group of GEM. Abrreviation: GEM, gemcitabine. | |||
| 0 | 2.895±0.055 | 2.825±0.057 | 0.976 |
| 0.25 | 1.204±0.048 | 1.272±0.080 | 1.056 |
| 0.50 | 0.964±0.037 | 1.142±0.118 | 1.185 |
| 1.00 | 0.809±0.032 | 0.855±0.086 | 1.057 |
| 2.00 | 0.721±0.024 | 0.835±0.071 | 1.158 |