Table 1.
Summary of the clinical, morphological, and genetic features of 18 cases with the diagnosis of high-grade/large B-cell lymphoma with 11q aberration
| Clinicopathological features |
High-grade B-cell lymphoma with 11q aberration/large B-cell lymphoma with 11q aberration |
|---|---|
| Age |
Median 22.5 years (range 7–72 years) |
| Sex | M:F 2.5:1 |
| Localization | |
| -Tonsils | 4 cases (22%) |
| -Lymph nodes | 7 cases (38%) |
| -Abdominal mass | 5 cases (28%) |
| -Ovary | 1 case (6%) |
| -Not available | 1 case (6%) |
| Clinical stage | |
| - Stage 1/2 | 12 cases (67%) |
| - Stage 3/4 | 6 cases (33%) |
| Cytology | |
| -Blastoid | 4 cases (22%) |
| -Intermediate, Burkitt like | 9 cases (50%) |
| -Large | 1 case (6%) |
| -Not available | 4 cases (22%) |
| Immunophenotype | |
| -CD10 | 17 cases (94%) |
| -BCL6 | 17 cases (94%) |
| -LMO2* | 7 cases (38%) |
| -BCL2 | 1 case (6%) |
| -MYC** | 18 cases (100%) |
| -MUM1 | 2 cases (12%) |
| FISH | |
| -11q gain | 18 cases (100%) |
| -11q loss | 18 cases (100%) |
| -IGH::MYC | 0 (0%) |
| -BCL2 | 0 (0%) |
| -BCL6 | 0 (0%) |
*Performed only on 15 cases in which the material was available; M male, F female