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. 2023 Sep 29;118(1):39. doi: 10.1007/s00395-023-01011-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Cultured adult rat ventricular cardiomyocyte (ARVC). A Artificially shadowed confocal microscopy image showing giant cylindrical shaped mitochondria (arrowhead). B Corresponding low magnification transmission electron microscopy image shows the presence of electron-dense inclusions in giant mitochondria. The inclusions can appear as parallel straight lines (arrow) or sheet liked wavy structures (arrowhead). N—nucleus. Periodicity was identified between the parallel straight lines C and within the linear structures (D, arrow). E–F ARVCs gold-labelled with mitochondrial creatine kinase antibody are localized at the site of both forms of the mitochondrial inclusions, but largely absent from mitochondria (m) without inclusions. Scale bars, 15 μm (A); 3 μm (B); 0.45 μm (C & D); 0.5 μm (E & F). (Figs. 1F, 3 and 4: Journal of Cell Biology by The Rockefeller University Press [16]. Reproduced and lettering modified with permission of The Rockefeller University Press in the format Journal/Magazine via Copyright Clearance Center)