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. 2023 Sep 29;118(1):39. doi: 10.1007/s00395-023-01011-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Electron microscopy observations of mitochondria in the naked mole rat. A shows the presence of a large mitochondrion (arrow) at 5 years of age. Note, the high number of normal-sized mitochondria surrounding the enlarged mitochondrion. B High magnification of the giant mitochondrion from A which illustrates packed wave-like cristae. Note the electron-dense granules scattered throughout the mitochondrial matrix. C At 11-year-old, the large mitochondria show inclusion of highly ordered cristae bundles and a clear reduction in cristae packing. D High magnification of the cristae bundles in C which are arranged in parallel, with a track-like appearance between the double-membraned structures termed membrane junctions or intra-crystal junctions. E Overview of the disrupted mitochondria ultrastructure in 11 year-old naked mole rats with possible sheet-like inclusions. Scale bars, 5 μm (A); 2 μm (B); 1 μm (C); 0.1 μm (D); 2 μm (E). (Figs. 5 and 8: International Journal of Molecular Sciences by MDPI [5]. Reproduced and lettering modified with permission of MDPI in the format Journal/Magazine via MDPI Open Access Policy)