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. 2023 Sep 29;118(1):39. doi: 10.1007/s00395-023-01011-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Electron microscopy micrographs showing ultrastructural changes of mitochondria in patients with mtDNA mutations. A Ring-shaped mitochondria. B Giant mitochondria with membrane fusion and circular cristae. C Concentric cristae. D Giant ‘organelles’ containing irregularly whorled and undulated cristae. End magnifications, × 5600 (A); × 16,000 (B); × 9600 (C); × 9100 (D). (Fig. 1: American Journal of Pathology by Elsevier [4]. Reproduced and lettering modified with permission of Elsevier’s Open Access Content License policy for the American Society for Investigative Pathology in the format Journal/Magazine and subject to proper acknowledgement of the original source)