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. 2023 Sep 29;118(1):39. doi: 10.1007/s00395-023-01011-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Fusion and fission events of cultured adult cardiomyocytes. A normal mitochondria. B Fusion of 2–3 mitochondria to form giant mitochondria mediated by Drp1 inhibition. Arrow denotes the area were mitochondria fused. C Mfn1/2 (mitofusins 1 and 2) knockout causes mitochondrial fragmentation (arrow). Note that the mitochondria are rounder and their size decreased. Scale bars, 0.5 μm. (Fig. 3: Frontiers in Cell and Developmental Biology by Frontiers Media SA [36]. Reproduced and lettering modified with permission of Frontiers Media SA in the format Journal/Magazine via Frontiers Copyright Notice Open Policy)