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. 2023 Sep 29;14:6088. doi: 10.1038/s41467-023-41753-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Representative images of CFP and YFP fluorescence from RPE1 Plk1-FRET Sensor cells treated with indicated inhibitors/drugs targeting indicated actors of the DNA damage repair pathway. B Violin plots of YFP/CFP intensity ratios from cells in A [N = 3 independent experiments, n = 146 (Cdk4/6i), 146 (Cdk1i), 146 (Eg5i), 151 (Plk1i), 149 (Aph), 151 (Eg5i+ATMi), 156 (Eg5i+ATRi), 159 (Aph+ATMi) and 159 (Aph+ATRi); p-values from Dunn’s multiple comparison test]. C Representative images of CFP and YFP fluorescence from RPE1 Plk1-FRET Sensor cells treated with indicated inhibitors/drugs against DNA repair pathway proteins. D Violin plots of YFP/CFP intensity ratios from cells in C [N = 3 independent experiments, n = 152 (Cdk4/6i), 173 (Cdk1i), 178 (Eg5i), 175 (Plk1i), 176 (Aph), 180 (Eg5i+Chk1i), 181 (Eg5i+Chk2i), 176 (Aph+Chk1i) and 185 (Aph+Chk2i): p-values from Dunn’s multiple comparison test]. Median in each case is marked with a bold black line and thin grey lines denote the 1st and 3rd quartiles. Scale bars = 0.5 µm. Source data for all graphs are provided as a Source Data file.