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. 2023 Sep 29;14:6099. doi: 10.1038/s41467-023-41849-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Cold promotes recruitment of peroxisomes to mitochondria in brown adipocytes. Peroxisomes cooperate with the endoplasmic reticulum (ER) to synthesize plasmalogens, which are incorporated into mitochondrial membrane. Plasmalogens facilitate membrane fusion and translocation of the peroxisomal transmembrane protein TMEM135 to the outer mitochondrial membrane (OMM). TMEM135 interacts with AKAP1 to promote PKA-mediated phosphorylation of Drp1. This activates mitochondrial fission, leading to increased uncoupled respiration and thermogenesis. Created with BioRender.com.