Table 2.
MANCOVA comparing HC, PD-CN, PD-MCI, and PD-D groups, adjusting for age, gender, education, and eTIV, according to nuclear parcellation
| MANCOVA | HC versus PD-CN |
HC versus PD-MCI |
HC versus PD-D |
PD-CN versus PD-MCI |
PD-CN versus PD-D |
PD-MCI versus PDD | |
|---|---|---|---|---|---|---|---|
| Left amygdala | |||||||
| Lateral nucleus | F(3,64) = 1.465, P = 0.232 | P = 1.000 | P = 0.306 | P = 0.747 | P = 0.751 | P = 1.000 | P = 1.000 |
| Basal nucleus | F(3,64) = 4.043, P = 0.011a | P = 1.000 | P = 0.014 | P = 0.033 | P = 0.112 | P = 0.197 | P = 1.000 |
| Accessory basal nucleus | F(3,64) = 2.206, P = 0.096 | P = 1.000 | P = 0.845 | P = 1.000 | P = 0.092 | P = 0.338 | P = 1.000 |
| Anterior amygdala area | F(3,64) = 1.805, P = 0.155 | P = 1.000 | P = 0.587 | P = 1.000 | P = 0.217 | P = 0.484 | P = 1.000 |
| Central nucleus | F(3,64) = 0.621, P = 0.604 | P = 1.000 | P = 1.000 | P = 1.000 | P = 0.552 | P = 1.000 | P = 1.000 |
| Medial nucleus | F(3,64) = 0.417, P = 0.741 | P = 1.000 | P = 1.000 | P = 1.000 | P = 0.552 | P = 1.000 | P = 1.000 |
| Cortical nucleus | F(3,64) = 2.850, P = 0.044a | P = 1.000 | P = 0.800 | P = 0.463 | P = 0.117 | P = 0.051 | P = 1.000 |
| Cortico-amygdaloid transition area | F(3,64) = 32.583, P = 6.6 × 10− 13 | P = 0.571 | P = 1.3 × 10− 10 | P = 4.6 × 10− 10 | P = 8.5 × 10− 10 | P = 1.4 × 10− 9 | P = 1.000 |
| Paralaminar nucleus | F(3,64) = 0.548, P = 0.651 | P = 1.000 | P = 1.000 | P = 1.000 | P = 1.000 | P = 1.000 | P = 1.000 |
| Right amygdala | |||||||
| Lateral nucleus | F(3,64) = 2.870, P = 0.043a | P = 0.201 | P = 0.047 | P = 0.078 | P = 1.000 | P = 1.000 | P = 1.000 |
| Basal nucleus | F(3,64) = 0.213, P = 0.887 | P = 1.000 | P = 1.000 | P = 1.000 | P = 1.000 | P = 1.000 | P = 1.000 |
| Accessory basal nucleus | F(3,64) = 0.947, P = 0.423 | P = 1.000 | P = 1.000 | P = 0.954 | P = 1.000 | P = 0.725 | P = 1.000 |
| Anterior amygdala area | F(3,64) = 1.231, P = 0.306 | P = 1.000 | P = 1.000 | P = 1.000 | P = 1.000 | P = 0.362 | P = 1.000 |
| Central nucleus | F(3,64) = 1.569, P = 0.206 | P = 1.000 | P = 1.000 | P = 1.000 | P = 1.000 | P = 1.000 | P = 0.232 |
| Medial nucleus | F(3,64) = 2.724, P = 0.051 | P = 1.000 | P = 1.000 | P = 0.122 | P = 1.000 | P = 0.322 | P = 0.088 |
| Cortical nucleus | F(3,64) = 1.967, P = 0.128 | P = 1.000 | P = 1.000 | P = 1.000 | P = 1.000 | P = 0.725 | P = 0.163 |
| Cortico-amygdaloid transition area | F(3,64) = 14.929, P = 1.8 × 10− 7 | P = 0.561 | P = 9.3 × 10− 7 | P = 1.1 × 10− 5 | P = 2.1 × 10− 5 | P = 1.5 × 10− 4 | P = 1.000 |
| Paralaminar nucleus | F(3,64) = 0.426, P = 0.735 | P = 1.000 | P = 1.000 | P = 1.000 | P = 1.000 | P = 1.000 | P = 1.000 |
Bonferroni corrected alpha level 0.00028 for MANCOVA, 0.00046 for multiple comparisons, aThese significant contrasts do not survive Bonferroni correction. HC = Healthy control, PD-CN = Cognitively normal PD, PD-MCI = PD with mild cognitive impairment, PD-D = PD with dementia