Fig. 4.

Time evolutions of membrane voltages (mV) for individual network neurons in a window of 3000–4000 ms. a In normal states, all neurons of the network exhibit random irregular firing patterns (BI = 1.16). b In OCD pathological states (decreasing the synaptic conductance of the FSI-MSN by 50% and increasing hyperdirect pathway strength by 50%, same in Fig. 5, 6, 7a, 15), firing patterns change significantly (BI = 3.24). The firing rate of the D1-MSN increases and burst patterns occur in STN, TC, and COR-E neurons