A03 Mineo.

Methods	RCT: 1988 to 1994
Participants	66 patients Stage IB
Interventions	surgery vs surgery + chemotherapy 6 cycles of chemotherapy cisplatin 100 mg/m2etoposide 120 mg/m2 Complete resection
Outcomes	Overall survival 5 year recurrence‐free survival Recurrence rates Cause of death
Notes	140 patients in trial, only 66 reported at time of data collection, therefore only 66 patients included
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Data checks on IPD provided suggest adequate sequence generation
Allocation concealment (selection bias)	Low risk	Central computer randomisation
Selective reporting (reporting bias)	Low risk	IPD supplied for outcomes
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Trial not blinded due to nature of intervention, outcome not likely to be influenced by lack of blinding
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Trial not blinded due to nature of intervention, primary outcome not likely to be influenced by lack of blinding