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[Preprint]. 2023 Nov 29:2023.09.15.557794. Originally published 2023 Sep 18. [Version 2] doi: 10.1101/2023.09.15.557794

Figure 6. Summary of key findings.

Figure 6.

The key findings of our study are represented, starting on the left, by showing the increased cardiac infiltration of CD4 T cells (CD4T), CD8 T cells (CD8T), mononuclear phagocytes (MNP), and conventional dendritic cells (cDCs). These immune cells are shown expressing some of the genes (ITGA4 and ITGAL on CD8T cells; CXCR3 on cycling CD8T; FLT3 on cDCs) that are anticipated to be involved in the recruitment and retention of immune cells into the heart by cognate ligands expressed by other cells in the heart (CXCL9/10 and FLT3LG in endothelial cells; CXCL9/10, ICAM1, and VCAM in pericytes; CXCL9/10 in MNPs; CXCL9 and FLT3LG on fibroblasts). Secreted CXCL9 and CXCL10 are highlighted as proteins that are elevated in the blood of irMyocarditis patients. “Correlates of severity” highlight factors in our scRNA-seq analysis that are associated with fatality (increased sharing of TCR clones expanded in the heart with cycling CD8T cells in the blood) and increased serum troponin in irMyocarditis patients (increased cDCs and cycling CD8T in the heart). An illustration of the heart and paired tumor highlight T cells with distinct colors to emphasize the finding that different T-cell clones are enriched in irMyocarditis and tumor compared to controls.