TABLE 2.
Pharmacokinetic parameters of itraconazole and hydroxyitraconazolea
| Age (yr) | Itraconazole
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Day 1
|
Day 14
|
|||||||||
| Tmax (h) | Cmax (ng/ml) | AUC (ng · h/ml) | Predose concn (ng/ml) | Tmax (h) | Cmax (ng/ml) | AUC (ng · h/ml) | R | t1/2term (h) | ||
| 0.5–2 | 2.9 ± 1.1 | 138 ± 91 | 1,340 ± 780 | 159 ± 218 | 1.9 ± 0.1 | 571 ± 416 | 6,930 ± 5,830 | 6.2 ± 5.0 | 47.4 ± 55.0 | |
| 2–5 | 2.4 ± 0.8 | 314 ± 105 | 2,740 ± 1,080 | 179 ± 101 | 2.9 ± 2.5 | 534 ± 431 | 7,330 ± 5,420 | 3.3 ± 3.0 | 30.6 ± 25.3 | |
| 5–12 | 2.8 ± 1.8 | 298 ± 292 | 2,010 ± 1,580 | 223 ± 145 | 3.1 ± 2.1 | 631 ± 358 | 8,770 ± 5,050 | 8.6 ± 7.4 | 28.3 ± 9.6 | |
| 3.9 ± 2.7 | 179 ± 101 | 2,340 ± 1,490 | 1.6 ± 0.6 | 308 ± 436 | 4.4 ± 2.3 | 690 ± 445 | 13,200 ± 11,400 | 11.4 ± 16.0 | 1.7 ± 0.7 | 18.0 ± 18.1 |
| 4.1 ± 2.7 | 493 ± 106 | 6,730 ± 1,950 | 2.6 ± 0.6 | 487 ± 314 | 4.8 ± 2.7 | 687 ± 419 | 13,400 ± 9,110 | 2.3 ± 1.9 | 2.1 ± 0.7 | 17.1 ± 14.5 |
| 3.1 ± 1.8 | 447 ± 365 | 4,920 ± 4,390 | 2.4 ± 0.6 | 437 ± 246 | 10.8 ± 14.3 | 699 ± 234 | 13,450 ± 7,190 | 6.4 ± 5.6 | 1.7 ± 0.5 | 17.9 ± 8.7 |
a
Data are means ± standard deviations.